RESUMEN
The immunopathology of T4 & T8 cell subsets in gingival tissues from 20 patients affected with either juvenile (JP) or rapidly progressive periodontitis (RPP) were studied using immunoperoxidase method for monoclonal antibodies of T4 & T8. Results were compared with gingival samples taken from systemically and periodontally healthy subjects. T4 subsets were found to be significantly elevated in JP & RPP, when compared with controls. Yet it was found to be higher in JP than in RPP, while T8 subsets were found to be depressed in both types of diseases. Those findings could contribute to the immunopathogenesis of JP & RPP.
Asunto(s)
Periodontitis Agresiva/inmunología , Periodontitis/inmunología , Subgrupos de Linfocitos T/inmunología , Adolescente , Adulto , Periodontitis Agresiva/patología , Biopsia , Linfocitos T CD4-Positivos/inmunología , Linfocitos T CD8-positivos/inmunología , Progresión de la Enfermedad , Femenino , Encía/inmunología , Encía/patología , Humanos , Técnicas Inmunológicas , Masculino , Periodontitis/patologíaRESUMEN
Inflammation of human gingival tissues including the periodontal structures occurs in response to infection in crevicular sulcus caused by microorganisms which first attach to the surface of oral squamous epithelium, penetrate into inner gingival epithelium and finally through the basement membrane of the underlying connective tissue (Murase et al., 1985). Other authors have long held the view that periodontitis is not a homogeneous disease entity but rather a group of family related diseases manifesting similar features and different etiologic factors. Immunological mechanism have long been implicated in pathogenesis of chronic periodontitis. Defect of host mechanism may have a relationship in development of rapidly progressive periodontitis (RPP) (Page et al., 1983).