Asunto(s)
Hernia Inguinal , Intestino Delgado , Humanos , Masculino , Hernia Inguinal/diagnóstico , Hernia Inguinal/complicaciones , Hernia Inguinal/cirugía , Hernia Inguinal/diagnóstico por imagen , Intestino Delgado/patología , Intestino Delgado/diagnóstico por imagen , Persona de Mediana Edad , Rotura/etiología , Traumatismos Abdominales/complicaciones , Patologia Forense/métodos , Ultrasonografía , Perineo/lesiones , Escroto/diagnóstico por imagen , Escroto/lesiones , Escroto/patología , Tomografía Computarizada por Rayos XAsunto(s)
Sepsis , Humanos , Persona de Mediana Edad , Femenino , Sepsis/diagnóstico , Sepsis/etiología , Medicamentos Herbarios Chinos/administración & dosificación , Medicamentos Herbarios Chinos/efectos adversos , Bacteriemia/diagnóstico , Bacteriemia/microbiología , Bacteriemia/tratamiento farmacológico , Insuficiencia Multiorgánica/etiología , Insuficiencia Multiorgánica/diagnóstico , Resultado Fatal , Polipéptido alfa Relacionado con Calcitonina/sangreAsunto(s)
Traumatismos Abdominales , Traumatismos Torácicos , Humanos , Accidentes de Tránsito , Colon Sigmoide , Medicina Legal , Autopsia , RoturaAsunto(s)
Fibrilación Atrial , Taponamiento Cardíaco , Ablación por Catéter , Ablación por Radiofrecuencia , Fibrilación Atrial/complicaciones , Fibrilación Atrial/cirugía , Taponamiento Cardíaco/etiología , Taponamiento Cardíaco/cirugía , Ablación por Catéter/efectos adversos , Humanos , Resultado del Tratamiento , Vena Cava Superior/diagnóstico por imagen , Vena Cava Superior/cirugíaRESUMEN
Inhibitory neurons take on many forms and functions. How this diversity contributes to memory function is not completely known. Previous formal studies indicate inhibition differentiated by local and global connectivity in associative memory networks functions to rescale the level of retrieval of excitatory assemblies. However, such studies lack biological details such as a distinction between types of neurons (excitatory and inhibitory), unrealistic connection schemas, and nonsparse assemblies. In this study, we present a rate-based cortical model where neurons are distinguished (as excitatory, local inhibitory, or global inhibitory), connected more realistically, and where memory items correspond to sparse excitatory assemblies. We use this model to study how local-global inhibition balance can alter memory retrieval in associative memory structures, including naturalistic and artificial structures. Experimental studies have reported inhibitory neurons and their subtypes uniquely respond to specific stimuli and can form sophisticated, joint excitatory-inhibitory assemblies. Our model suggests such joint assemblies, as well as a distribution and rebalancing of overall inhibition between two inhibitory subpopulations, one connected to excitatory assemblies locally and the other connected globally, can quadruple the range of retrieval across related memories. We identify a possible functional role for local-global inhibitory balance to, in the context of choice or preference of relationships, permit and maintain a broader range of memory items when local inhibition is dominant and conversely consolidate and strengthen a smaller range of memory items when global inhibition is dominant. This model, while still theoretical, therefore highlights a potentially biologically-plausible and behaviorally-useful function of inhibitory diversity in memory.