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Mem. Inst. Oswaldo Cruz ; Mem. Inst. Oswaldo Cruz;99(3)May 2004. tab, ilus, graf
Artículo en Español | CUMED | ID: cum-40095

RESUMEN

Current therapy for leishmaniasis is not satisfactory. We describe the in vitro antiproliferative effects of new thiadiazine derivatives against Leishmania amazonensis. The compounds were found to be active against the amastigote form of the parasite, inhibiting parasite growing, from 10 to 89 percent, at a concentration of 100 ng/ml. This activity suggests that thiadiazine derivatives could be considered as potential antileishmanial compounds(AU)


Asunto(s)
Animales , Ratones , Antiprotozoarios/farmacología , Leishmania braziliensis , Tiadiazinas/farmacología
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